Publications and Dissemination

  1. D. Braga, M. Barcella, A. Herpain, F. Aletti, E.B. Kistler, B. Bollen Pinto, K. Bendjelid, C. Barlassina (2019), “A longitudinal study highlights shared aspects of the transcriptomic response to cardiogenic and septic shock”, Critical Care 2019: 23, 414. doi:10.1186/s13054-019-2670-8.
  2. M. Carrara, A. Herpain, G. Baselli,  M.Ferrario (2019), “A mathematical model of dP/dt max for the evaluation of the dynamic control of heart contractility in septic shock”,  IEEE Transactions on Biomedical Engineering, doi: 10.1109/TBME.2019.2894333
  3. M. Ferrario, L. Brunelli, F. Su, A. Herpain, R. Pastorelli (2019), “The systemic alterations of lipids, alanine-glucose cycle and inter-organ amino acid metabolism in swine model confirms the role of liver in early phase of septic shock”. Front. Physiol. doi: 10.3389/fphys.2019.00011
  4. M. Barcella, B. Bollen Pinto, D. Braga, F. D’Avila, F. Tagliaferri, M.A. Cazalis, G. Monneret, A.Herpain, K. Bendjelid, C. Barlassina (2018), “Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy”, Critical Care 2018, 22:312. doi:10.1186/s13054-018-2242-3
  5. J.Bauzá-Martinez, F.Aletti, B.B.Pinto, V.Ribas, M.A.Odena, R.Díaz, E.Romay, R.Ferrer, E.B.Kistler, G.Tedeschi, G.W.Schmid-Schönbein, A.Herpain, K.Bendjelid, E.de Oliveira (2018), “Proteolysis in septic shock patients: plasma peptidomic patterns are associated with mortality”, British Journal of Anaesthesia. 121(5):1065-1074. DOI: 10.1016/j.bja.2018.05.072
  6. M. Carrara, G.Babini, G. Baselli, G. Ristagno, R. Pastorelli, L. Brunelli, M. Ferrario (2018), “Blood pressure variability, heart functionality and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation”, J Appl Physiol 125: 1011–1020, 2018. doi: 10.1152/japplphysiol.00348.2018
  7. A. Cambiaghi, R. Díaz, J. Bauzá; A. Odena, L. Brunelli, P Caironi, S. Masson, G. Baselli, G. Ristagno, L Gattinoni, E. de Oliveira, R. Pastorelli, M Ferrario (2018), “Integration of metabolomics and proteomics data for early mortality prediction in severe septic shock patients”, Scientific Reports 8, 6681 (2018). doi:10.1038/s41598-018-25035-1
  8. M. Carrara, B. Pinto Bollen, G. Baselli, K. Bendjelid, M. Ferrario (2017) “Baroreflex sensitivity and blood pressure variability can help in understanding the different response to therapy during acute phase of septic shock”, Shock (Augusta, Ga.). doi: 10.1097/SHK.0000000000001046
  9. A. Cambiaghi, B Bollen Pinto, L. Brunelli, F Falcetta, F Aletti , K. Bendjelid , R. Pastorelli, M. Ferrario (2017) “Characterization of a metabolomic profile associated with responsiveness to therapy in the acute phase of septic shock”, Scientific reports, 7(1), 9748. doi:10.1038/s41598-017-09619-x
  10. B. Bollen Pinto, C. Ritter, M. Michels, N. Gambarotta, M. Ferrario, F. Dal-Pizzol, M. Singer, (2017) “Characterization of brain-heart interactions in a rodent model of sepsis”, Molecular neurobiology, 54(3), pp.3745-3752, doi: 10.1007/s12035-016-9941-z.
  11. M. Lavanga, G. Baselli, F. Fumagalli, G. Ristagno, M. Ferrario (2016) “The possible role of the vagal nervous system in the recovery of the blood pressure control after cardiac arrest: a porcine model study”, Physiological Measurement, 38 (1), pp 63-76. DOI: 10.1088/1361-6579/38/1/63
  12. A. Cambiaghi, M. Ferrario, M. Masseroli (2016), “Analysis of metabolomic data: tools, current strategies and future challenges for omics data integration”, Briefings in Bioinformatics, 18(3), 1 May 2017, pp: 498-510. DOI: 10.1093/bib/bbw031
  13. N. Gambarotta, G. Baselli, F. Aletti, M. Ferrario (2016), “A review of methods for the signal quality assessment to improve reliability of heart rate and blood pressures derived parameters”, Medical & Biological Engineering & Computing, 54(7): pp. 1025-1035, doi: 10.1007/s11517-016-1453-5
  14. M. Ferrario, A. Cambiaghi, L. Brunelli, S. Giordano, P. Caironi, L. Guatteri, F. Raimondi, L. Gattinoni, R. Latini, S. Masson, G. Ristagno, R. Pastorelli (2016) “Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach”, Scientific Reports, 6: 20391. doi:10.1038/srep20391.
  15. F. Aletti, C. Conti, M. Ferrario, V. Ribas, B. Bollen Pinto, A. Herpain, E. Post, E. Romay Medina, C. Barlassina, E. de Oliveira, R. Pastorelli, G. Tedeschi, G.Ristagno, F.S. Taccone, G.W. Schmid-Schönbein, R. Ferrer, D. De Backer, K.Bendjelid, G. Baselli (2016), “ShockOmics: multiscale approach to the identification of molecular biomarkers in acute heart failure induced by shock”, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 24:9. DOI: 10.1186/s13049-016-0197-4
  16. Aletti, N. Gambarotta, A. H Penn, M. Ferrario, Geert W Schmid-Schönbein (2015), “Heart period and blood pressure characteristics in splanchnic arterial occlusion shock-induced collapse”, J Clin Monit Comput. 2017 Feb;31(1):167-175, doi: 10.1007/s10877-015-9813-5
  17. M. Carrara, G. Baselli, M. Ferrario (2015), “Mortality prediction model of septic shock patients based on routinely recorded data”, Computational and Mathematical Methods in Medicine, vol. 2015, Article ID 761435. DOI: 10.1155/2015/761435
  18. H. Santamaria et al. (2017) “Enteral tranexamic acid attenuates vasopressor resistance and changes in α1-adrenergic receptor expression in hemorrhagic shock.”Journal of Trauma and Acute Care Surgery 83.2 (2017): 263-270. doi:10.1097/TA.0000000000001513
  19. D. Braga, et al. “Preliminary profiling of blood transcriptome in a rat model of hemorrhagic shock” Experimental Biology and Medicine 242.14 (2017): 1462-1470.  doi: 10.1177/1535370217717978
  20. F. Aletti, E. Maffioli, A.  Negri, M.H. Santamaria, F.A. DeLano, E. Kistler, G.W. Schmid-Schönbein, G. Tedeschi (2016) “Peptidomic analysis of rat plasma: proteolysis in hemorrhagic shock.” Shock (Augusta, Ga.) 45.5: 540. doi: 10.1097/SHK.0000000000000532

Other dissemination activities

  1. Cardiovascular variability and intra-surgical monitoring of autonomic control, 3rd International Conference on Computational & Mathematical Biomedical Engineering. Hong-Kong, 16-18 December 2013.
  2. Baroreflex sensitivity during intestinal ischemia, Experimental Biology. Experimental Biology, San Diego (USA), 26-30 April 2014
  3. Continuous blood pressure assessment from a photoplethysmographic signal with Deep Belief Networks. Experimental Biology, San Diego (USA), 26-30 April 2014.
  4. Baroreflex sensitivity during shock induced by intestinal ischemia. Annual Conference of the IEEE Engineering in Medicine and Biology Society, Chicago (USA) August 26-30, 2014
  5. Critical analysis of cardiovascular variability as a tool for studying autonomic nervous system, Symposium on Autonomic neural regulation of the immune system. Sao Paolo (Brazil), 11 August 2014.
  6. Assessment of Electrocardiograms with Pretraining and Shallow Networks, Computing in Cardiology. Boston (USA), 7-10 September 2014
  7. ProteoSepsis: Proteomic analysis of plasma proteins during the course of sepsis. Human proteome Organization World Congress. Madrid (Spain). 5-8 October 2014
  8. Effect of digestive enzyme inhibition in the intestine on protease activity levels in the heart in hemorrhagic shock. 38th Annual Conference on Shock. Denver (USA). June 6 – 9, 2015.
  9. Peptidome characterization of plasma samples from healthy and hemorrhagic-shock rats. European Proteomics Association. Milano (Italy) 23-28 June 2018
  10. Mortality prediction model of septic shock patients based on routinely recorded data. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), August 25-29 2015
  11. Metabolite analysis in sepsis through conditional independence maps. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), August 25-29 2015
  12. Proteomic analysis of plasma peptidome in healthy and hemorrhagic-shock rats. 58th National Meeting of the Italian Society of Biochemistry and Molecular Biology (SIB) – Urbino, September 14-16
  13. Target metabolomics for improving early prediction of death in patients with septic shock. 16th Congress of the EUROPEAN SHOCK SOCIETY (ESS), Cologne, Germany, 24-26 September 2015
  14. Peptidomics of plasma in shock, Riunione dei biochimici dell’area Milanese, Gargnano, Italy. 20-22 March 2016.
  15. Plasma peptidome in hemorragic shock. Bologna, Italy. 30 March-1 April 2016
  16. A classification model based on metabolomics and proteomics for acute traumatic coagulopathy patients: a feasibility study. 39th Annual Conference on Shock. Austin (USA). June 11 – 14, 2016.
  17. Metabolomic state as early indicator of organ worsening in septic shock patients: feasibility study for small data sample. 12th Annual Conference of the Metabolomics Society, Dublin, 27-30 June 2016
  18. Multiscale modelling of mortality risk in a septic shock population. V Congresso del Gruppo Nazionale di Bioingegneria. Naples (Italy). 20-22June 2016
  19. Advancement of the ShockOmics EC Project. 15th International Conference on Complex Acute Illness. Pasadena(USA). August 10-14, 2016
  20. Baroreflex analysis in the recovery after cardiac arrest in a porcine model. 15th International Conference on Complex Acute Illness. Pasadena(USA). August 10-14, 2016
  21. Merging physiological and statistical models for a better understanding of shock. 15th International Conference on Complex Acute Illness. Pasadena(USA). August 10-14, 2016.
  22. Proteomic analysis of plasma peptidome in healthy and hemorrhagic-shock rats. 16th Congress of the EUROPEAN SHOCK SOCIETY (ESS), Cologne, Germany, 24-26 September 2015
  23. Autonomic nervous system indices in the progression of organ failure in early septic shock patients. 15th International Conference on Complex Acute Illness. Pasadena(USA). August 10-14, 2016.
  24. Association between autonomic imbalance and recovery of organ function in early septic shock. ESICM LIVES 2016, Milano, Italy. 1-5 October 2016.
  25. Transcriptomic profile in septic shock patients: a preliminary analysis. S. Paolo Hospital – Milan (Italy), November 11,  2016
  26. Peptidomic characterization of plasma samples: effects of tranexamic acid against proteolysis in hemorrhagic shock. 7th Proteonet Meeting, Proteomics in Drug Discovery. Milan (Italy). 11 May 2017
  27. Different response to therapy in septic shock: an autonomic perspective. 40th Annual Conference on Shock, Fort Laurendale, FL, USA. June 3 – 6, 2017.
  28. Preliminary analysis of transcriptomic modifications in septic shock patients at multiple time points. 40th Annual Conference on Shock, Fort Laurendale, FL, USA. June 3 – 6, 2017.
  29. Responsiveness to therapy in the acute phase of septic shock: a metabolomics analysis. 40th Annual Conference on Shock, Fort Laurendale, FL, USA. June 3 – 6, 2017
  30. Peptidomic analysis of rat plasma: effects of tranexamic acid against proteolysis in hemorrhagic shock. Riunione dei biochimici dell’area Milanese, Gargnano, Italy. 25-27 June 2017
  31. Metabolomic state as early indicator of responsiveness to therapy in the acute phase of septic shock. 16th International Conference on Complex Acute Illness, Milano (Italy). 27-29 July 2017
  32. The role of fluid accumulation in early septic shock: differences in ANS- 
driven response to therapy. 16th International Conference on Complex Acute Illness, Milano (Italy). 27-29 July 2017
  33. Autodigestion as Mechanism for Multi-Organ Failure in Shock. 16th International Conference on Complex Acute Illness, Milano (Italy). 27-29 July 2017
  34. Peptidomic characterization of hemorrhagic shock plasma samples: effects 
of tranexamic acid. 16th International Conference on Complex Acute Illness, Milano (Italy). 27-29 July 2017
  35. Clustering Shock in the Acute Phase using Graphical Models. 16th International Conference on Complex Acute Illness, Milano (Italy). 27-29 July 2017
  36. Enteral protease inhibition in hemorrhagic shock: effect on autonomic. 16th International Conference on Complex Acute Illness, Milano (Italy). 27-29 July 2017
  37. A porcine model of severe hemorrhagic shock with fluid and blood resuscitation to evaluate plasma peptidomic modifications. 16th International Conference on Complex Acute Illness, Milano (Italy). 27-29 July 2017
  38. Peptidomics: an innovative approach to Study the Auto-digestionhypothesis in Septic Shock 
 16th International Conference on Complex Acute Illness, Milano (Italy). 27-29 July 2017
  39. Differential gene expression in septic shock patients according to the early supportive therapy 
 16th International Conference on Complex Acute Illness, Milano (Italy). 27-29 July 2017
  40. An in vitro model for cardiogenic and septic shock drug screening using microfluidics. 16th International Conference on Complex Acute Illness, Milano (Italy). 27-29 July 2017